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Melanotan 1

Melanotan 1

Dual-Chamber Pen

Melanotan 1 Peptide Pen is available in a 10 mg strength and contains a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH), commonly known as afamelanotide. Melanotan 1 has attracted research interest primarily for its effects on melanin production, skin pigmentation and the biological response to UV exposure.

Its activity is strongly associated with the melanocortin-1 receptor (MC1R), which plays a central role in controlling melanin production within pigment-producing cells. Research has also explored how this pathway relates to photoprotection, oxidative stress and cellular responses to light exposure.

PCP’s proprietary Dual-Chamber Technology keeps the lyophilised Melanotan 1 separate from the bacteriostatic water until activation.

For laboratory research use only. Not intended for human or veterinary use.

Strength
1.090,00 CZK
1.090,00 CZK
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Product Details

The Melanotan 1 Dual-Chamber Peptide Pen is supplied in a preloaded format that keeps the lyophilised Melanotan 1 powder and diluent physically separated until preparation. This allows both components to remain unmixed during storage and transport.

Each pen is clearly identified and professionally packaged to support product protection, straightforward handling and reliable identification within qualified research environments.

Product highlights:

• Dual-chamber configuration with separately contained Melanotan 1 powder and diluent
• Supplied unmixed until laboratory preparation
• Available in a 10 mg strength
• Provides 100 dial units in total
• One complete dual-chamber cartridge per pen
• Five 32G × 4 mm needle tips included
• Protective packaging for storage and transport
• Certificate of Analysis (COA) available

Technical specifications, dial-unit information, storage requirements and handling guidance are provided to support product identification and responsible

Technical Specifications
Intended Use
For laboratory research use only. Not for human or veterinary use.
Shipping Condition
Securely packaged for transport with tracked delivery.
Storage Temperature
Unopened/unmixed: store refrigerated at 2–8°C. After mixing: store refrigerated at 2–8°C. Do not freeze. Protect from light.
Presentation
One pre-filled double-chamber research pen containing unmixed components, supplied with three 32G × 4 mm needle tips
Form
Lyophilized peptide powder and diluent maintained in separate chambers
Compound Identity
Compound: Melanotan 1

Compound type: Synthetic α-MSH-derived linear 13-amino-acid melanocortin analogue

Research classification: Melanocortin-1 receptor agonist investigated in connection with MC1R signalling, melanogenesis, pigment-cell biology and cellular responses to light-associated and oxidative stress

Refer to the applicable product and batch documentation for verified analytical and chemical identity information.
Pen Specifications

Each pen contains a 1 mL cartridge. The amount represented by one dial unit depends on the selected pen strength. The tables below show the corresponding values for each available strength.

Pen Specifications
Pen strength Cartridge 1 dial unit
10 mg 1 mL 0.1 mg

Dial-Unit Conversion Reference

The table shows the amount represented by each listed dial setting for the available pen strengths.

Dial-unit reference by pen strength
Dial units 10 mg
1 0.1 mg
4 0.4 mg
5 0.5 mg
10 1.0 mg
20 2.0 mg
40 4.0 mg

Research-use information: Dial-unit values are provided solely for product identification, quantitative laboratory planning and documentation. They are not administration or clinical dosing instructions.

Storage & Handling

Recommended storage: Unopened/unmixed: store refrigerated at 2–8°C. After mixing: store refrigerated at 2–8°C. Do not freeze. Protect from light.

Protect the product from light and moisture and minimise unnecessary exposure to room temperature.

Complete storage and handling guidance is provided in the product information section below.

Research Use Only

All Pencell Peptide (PCP) products are supplied exclusively for laboratory research use by qualified professionals. They are not intended for human or veterinary use, consumption, personal use, medical, therapeutic, or diagnostic applications. Customers are responsible for lawful purchase, storage, handling, use, and disposal in accordance with applicable regulations and approved laboratory procedures.

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Protected by Design

Peptide and diluent remain separate until preparation

≥98% Purity

HPLC verified for research grade quality

Controlled Conditions

Prepared with a focus on consistency and research quality

Certificate of Analysis

Provided with Every Lot

Scientific Overview

Scientific Background

Melanotan 1 is a synthetic 13-amino-acid peptide developed from naturally occurring alpha-melanocyte-stimulating hormone (α-MSH), an important signalling peptide within the melanocortin system that helps regulate melanin production and pigmentation.

Its sequence, Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂, contains two key substitutions compared with natural α-MSH: norleucine replaces methionine and D-phenylalanine replaces L-phenylalanine. These modifications increase peptide stability and provide a useful model for studying how small structural changes influence receptor activity and biological behaviour.

Melanotan 1 acts primarily through the melanocortin-1 receptor (MC1R) on pigment-producing melanocytes. Activation of MC1R stimulates melanogenesis, the biological process responsible for producing melanin, including eumelanin, the darker pigment associated with the skin’s natural response to UV exposure.

This connection makes Melanotan 1 particularly relevant for studying pigmentation, photoprotection and cellular responses to UV and oxidative stress, while also allowing researchers to examine how its modified α-MSH structure affects receptor binding, signalling and pigment-cell activity.

This information is provided as general scientific background for laboratory research purposes.
Research Context

Research Applications

Areas examined within controlled laboratory research.

Melanotan 1 is a synthetic 13-amino-acid peptide derived from naturally occurring alpha-melanocyte-stimulating hormone (α-MSH). Its sequence, Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂, includes norleucine and D-phenylalanine substitutions that improve peptide stability while maintaining activity within the melanocortin system.

Research into Melanotan 1 focuses particularly on the melanocortin-1 receptor (MC1R), a receptor found on melanocytes that plays a central role in controlling melanin production and skin pigmentation. Activation of this pathway promotes melanogenesis, making Melanotan 1 particularly useful for studying the biological mechanisms responsible for pigmentation.

Researchers also investigate how increased melanin production relates to the skin’s response to UV exposure, photoprotection and oxidative stress, as well as how structural modifications to α-MSH influence receptor activity and peptide stability.

Current areas of scientific investigation include:

  1. Melanocortin-1 receptor signalling (Melanotan 1)

    Research examining how Melanotan 1 interacts with MC1R and influences downstream intracellular signalling within controlled experimental models.

  2. Melanogenesis and pigment regulation (Melanotan 1)

    Studies exploring signalling processes associated with melanin synthesis, pigment production and regulation within melanocyte models.

  3. Peptide structure and stability (Melanotan 1)

    Investigation of how the norleucine and D-phenylalanine substitutions influence molecular stability, enzymatic resistance and experimental behaviour.

  4. Receptor binding and selectivity (Melanotan 1)

    Comparative research evaluating the binding profile and signalling activity of Melanotan 1 across melanocortin-receptor systems.

  5. Gene-expression responses (Melanotan 1)

    Studies examining changes in gene activity associated with MC1R signalling and melanocyte responses under controlled experimental conditions.

  6. Light-associated and oxidative stress (Melanotan 1)

    Research exploring pigment-cell responses to light-associated, oxidative and other forms of controlled cellular stress.

Studies of Melanotan 1 have explored how activation of the melanocortin-1 receptor (MC1R) influences melanin production and skin pigmentation. Research has shown that stimulating this pathway can increase eumelanin, the darker form of melanin that plays an important role in the skin’s natural response to UV exposure.

Researchers have also investigated how these changes in pigmentation relate to photoprotection, UV-induced cellular stress and oxidative damage, providing insight into the biological relationship between melanocortin signalling and the skin’s response to light.

Further research continues to examine how Melanotan 1’s modified α-MSH structure affects receptor activity, peptide stability and pigment-cell behaviour, helping connect its molecular design with the pigmentation responses observed experimentally.

For laboratory research purposes only. Not intended for human or veterinary use.

Important Notice Research Use Only View complete notice

All products supplied by Pencell Peptide (PCP), including its dual-chamber peptide research pens, are intended strictly for laboratory research purposes only.

These products are not intended for human or animal consumption, medical or veterinary use, therapeutic applications, diagnostic procedures or any other clinical purpose.

Customers are responsible for complying with all applicable laws, regulations and institutional requirements governing the purchase, possession, handling, storage and use of peptide research materials.

Read the complete Research Use Only notice .