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Retatrutide

Retatrutide

Dual-Chamber Pen

Retatrutide Peptide Pen contains a single engineered peptide that acts across three key metabolic receptors: GIP, GLP-1 and glucagon.

What makes Retatrutide particularly interesting is its triple-receptor activity. Studies have reported notable changes in body weight, blood sugar and other metabolic markers, leading to growing interest in its wider metabolic effects.

PCP’s proprietary Dual-Chamber Technology keeps the lyophilised peptide separate from the sterile diluent until activation, offering a practical, self-contained format for laboratory preparation.

For laboratory research use only. Not intended for human or veterinary use.

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2.990,00 CZK
2.990,00 CZK
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Product Details

The Retatrutide Dual-Chamber Research Pen is supplied as a complete, preloaded system containing lyophilised Retatrutide and sterile diluent in two physically separated chambers. The components remain unmixed throughout storage and transport and are combined only when the pen is activated for laboratory preparation.

Each strength is clearly identified and presented in protective packaging for straightforward product selection, handling and storage within qualified research environments.

Product highlights:

  • Proprietary dual-chamber configuration
  • Lyophilised Retatrutide and sterile diluent contained separately
  • Components remain unmixed until activation
  • Available in 10 mg, 20 mg and 40 mg strengths
  • Provides 100 dial units in total
  • One complete dual-chamber research pen
  • Five 32G × 4 mm needle tips included
  • Protective packaging for storage and transport
  • Certificate of Analysis (COA) available

Technical specifications, dial-unit information, storage conditions and handling guidance are provided separately to support accurate product identification and responsible laboratory use.

Technical Specifications
Intended Use
For laboratory research use only. Not for human or veterinary use.
Shipping Condition
Securely packaged for transport with tracked delivery.
Storage Temperature
Unopened/unmixed: store refrigerated at 2–8°C. After mixing: store refrigerated at 2–8°C. Do not freeze. Protect from light.
Presentation
One pre-filled double-chamber research pen containing unmixed components, supplied with three 32G × 4 mm needle tips
Form
Lyophilized peptide powder and diluent maintained in separate chambers
Compound Identity
Compound: Retatrutide

Compound type: Synthetic peptide-based research compound

Molecular profile: Single engineered peptide with agonist activity at the GIP, GLP-1 and glucagon receptors

Research classification: Triple-receptor agonist investigated in relation to incretin signalling, glucagon-receptor activity, metabolic regulation and coordinated multi-receptor pharmacology

Refer to the applicable product and batch documentation for verified analytical and chemical identity information.
Pen Specifications

Each pen contains a 1 mL cartridge. The amount represented by one dial unit depends on the selected pen strength. The tables below show the corresponding values for each available strength.

Pen Specifications
Pen strength Cartridge 1 dial unit
10 mg 1 mL 0.1 mg
20 mg 1 mL 0.2 mg
40 mg 1 mL 0.4 mg

Dial-Unit Conversion Reference

The table shows the amount represented by each listed dial setting for the available pen strengths.

Dial-unit reference by pen strength
Dial units 10 mg 20 mg 40 mg
1 0.1 mg 0.2 mg 0.4 mg
4 0.4 mg 0.8 mg 1.6 mg
5 0.5 mg 1.0 mg 2.0 mg
10 1.0 mg 2.0 mg 4.0 mg
20 2.0 mg 4.0 mg 8.0 mg
40 4.0 mg 8.0 mg 16.0 mg

Research-use information: Dial-unit values are provided solely for product identification, quantitative laboratory planning and documentation. They are not administration or clinical dosing instructions.

Storage & Handling

Recommended storage: Unopened/unmixed: store refrigerated at 2–8°C. After mixing: store refrigerated at 2–8°C. Do not freeze. Protect from light.

Protect the product from light and moisture and minimise unnecessary exposure to room temperature.

Complete storage and handling guidance is provided in the product information section below.

Research Use Only

All Pencell Peptide (PCP) products are supplied exclusively for laboratory research use by qualified professionals. They are not intended for human or veterinary use, consumption, personal use, medical, therapeutic, or diagnostic applications. Customers are responsible for lawful purchase, storage, handling, use, and disposal in accordance with applicable regulations and approved laboratory procedures.

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Protected by Design

Peptide and diluent remain separate until preparation

≥98% Purity

HPLC verified for research grade quality

Controlled Conditions

Prepared with a focus on consistency and research quality

Certificate of Analysis

Provided with Every Lot

Scientific Overview

Scientific Background

Retatrutide is a synthetic peptide composed of a specific sequence of amino acids. The arrangement of these amino acids helps determine the peptide’s structure, how it interacts with receptors and its resulting biological activity.

Retatrutide is described as a triple receptor agonist, activating the GIP (GIPR), GLP-1 (GLP-1R) and glucagon (GCGR) receptors. What makes it particularly distinctive is that all three activities are combined within a single engineered peptide. This allows researchers to examine how coordinated activation of these interconnected pathways differs from selective or dual-receptor signalling.

These receptor systems are involved in glucose regulation, energy balance and metabolic signalling. Research into Retatrutide therefore extends from receptor interactions and cellular responses to energy metabolism, hepatic pathways and cardiometabolic mechanisms, as well as the relationship between peptide structure and biological activity.

Both preclinical and clinical studies continue to investigate Retatrutide’s pharmacological properties and multi-receptor profile, building a broader understanding of how a single peptide can influence several connected metabolic pathways.

This information is provided as general scientific background for laboratory research purposes.
Research Context

Research Applications

Areas examined within controlled laboratory research.

Retatrutide has shown notable results in clinical studies, particularly across weight and metabolic health. In a Phase 2 trial, participants receiving the highest studied dose lost an average of 24.2% of their body weight over 48 weeks, alongside improvements in waist circumference and several metabolic measures.

Research has also reported substantial reductions in liver fat, while ongoing studies continue to examine Retatrutide’s effects on blood sugar control, cardiovascular risk factors and broader metabolic health.

Current areas of scientific investigation include:

  1. Hepatic and Cardiometabolic Research (Retatrutide)

    Investigation of molecular pathways associated with hepatic metabolism, lipid regulation, energy homeostasis and related cardiometabolic processes.

  2. Cellular and Molecular Responses

    Study of downstream signalling events, cellular responses and pathway-specific biological mechanisms following receptor activation.

  3. Endocrine Signalling

    Investigation of peptide-mediated receptor activity and its role in hormonal communication, endocrine regulation and coordination between biological systems.

  4. Metabolic Signalling

    Research into molecular pathways involved in glucose regulation, energy balance, nutrient-responsive signalling, lipid metabolism and broader metabolic processes.

  5. Multi-Receptor Pharmacology (Retatrutide)

    Investigation of Retatrutide's activity across the GIP, GLP-1 and glucagon receptors, including receptor binding, activation, selectivity and coordinated downstream signalling pathways.

  6. Peptide Structure and Function (Retatrutide)

    Investigation of how Retatrutide's amino acid sequence and molecular structure influence receptor interaction, triple-receptor activity and coordinated biological signalling.

  7. Comparative Peptide Research (Retatrutide)

    Comparison of Retatrutide with selective and dual-receptor peptide compounds to improve understanding of multi-receptor pharmacology, coordinated signalling and biological activity.

Research may include receptor-binding studies, functional activity assays, cellular models and comparative compound evaluation, helping researchers better understand how Retatrutide interacts with its three target receptors and how this activity compares with single- or dual-receptor compounds.

Experimental concentrations, controls and analytical methods should be selected by qualified researchers according to the requirements of each study.

Together, these approaches continue to build a clearer picture of Retatrutide’s receptor activity, molecular behaviour and wider metabolic signalling.

For laboratory research purposes only. Not intended for human or veterinary use.

Important Notice Research Use Only View complete notice

All products supplied by Pencell Peptide (PCP), including its dual-chamber peptide research pens, are intended strictly for laboratory research purposes only.

These products are not intended for human or animal consumption, medical or veterinary use, therapeutic applications, diagnostic procedures or any other clinical purpose.

Customers are responsible for complying with all applicable laws, regulations and institutional requirements governing the purchase, possession, handling, storage and use of peptide research materials.

Read the complete Research Use Only notice .