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Semax

Semax

Dual-Chamber Pen

Semax Peptide Pen is available in a 10 mg strength and contains a synthetic seven-amino-acid peptide derived from the ACTH(4–7) fragment, without the hormonal activity of the parent hormone. Semax has attracted research interest particularly for its potential effects on cognitive function, learning, memory, attention and neuronal protection.

Research has explored Semax in relation to neuroplasticity and neurotrophic factors such as BDNF, helping scientists investigate how the brain adapts, forms and maintains neural connections, and responds to cellular stress. These properties have made Semax particularly interesting in research into cognition, memory and neurological resilience.

PCP’s proprietary Dual-Chamber Technology keeps the lyophilised Semax separate from the bacteriostatic water until activation.

For laboratory research use only. Not intended for human or veterinary use.

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1.190,00 CZK
1.190,00 CZK
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Product Details

The Semax Dual-Chamber Peptide Pen is supplied in a preloaded format that keeps the lyophilised Semax powder and diluent physically separated until preparation. This allows the components to remain unmixed during storage and transport.

Each pen is clearly identified and professionally packaged to support product protection, straightforward handling and reliable identification within qualified research environments.

Product highlights:

• Dual-chamber configuration with separately contained Semax powder and diluent
• Supplied unmixed until laboratory preparation
• Available in a 10 mg strength
• Provides 100 dial units in total
• One complete dual-chamber cartridge per pen
• Five 32G × 4 mm needle tips included
• Protective packaging for storage and transport
• Certificate of Analysis (COA) available

Technical specifications, dial-unit information, storage requirements and handling guidance are provided to support product identification and responsible laboratory use.

Technical Specifications
Intended Use
For laboratory research use only. Not for human or veterinary use.
Shipping Condition
Securely packaged for transport with tracked delivery.
Storage Temperature
Unopened/unmixed: store refrigerated at 2–8°C. After mixing: store refrigerated at 2–8°C. Do not freeze. Protect from light.
Presentation
One pre-filled double-chamber research pen containing unmixed components, supplied with three 32G × 4 mm needle tips
Form
Lyophilized peptide powder and diluent maintained in separate chambers
Compound Identity
Compound: Semax

Compound type: Synthetic ACTH(4–7)-derived seven-amino-acid peptide

Research classification: Regulatory heptapeptide investigated in connection with neurobiological signalling, neurotransmitter-associated pathways, gene-expression responses and cellular stress-related processes

Refer to the applicable product and batch documentation for verified analytical and chemical identity information.
Pen Specifications

Each pen contains a 1 mL cartridge. The amount represented by one dial unit depends on the selected pen strength. The tables below show the corresponding values for each available strength.

Pen Specifications
Pen strength Cartridge 1 dial unit
10 mg 1 mL 0.1 mg

Dial-Unit Conversion Reference

The table shows the amount represented by each listed dial setting for the available pen strengths.

Dial-unit reference by pen strength
Dial units 10 mg
1 0.1 mg
4 0.4 mg
5 0.5 mg
10 1.0 mg
20 2.0 mg
40 4.0 mg

Research-use information: Dial-unit values are provided solely for product identification, quantitative laboratory planning and documentation. They are not administration or clinical dosing instructions.

Storage & Handling

Recommended storage: Unopened/unmixed: store refrigerated at 2–8°C. After mixing: store refrigerated at 2–8°C. Do not freeze. Protect from light.

Protect the product from light and moisture and minimise unnecessary exposure to room temperature.

Complete storage and handling guidance is provided in the product information section below.

Research Use Only

All Pencell Peptide (PCP) products are supplied exclusively for laboratory research use by qualified professionals. They are not intended for human or veterinary use, consumption, personal use, medical, therapeutic, or diagnostic applications. Customers are responsible for lawful purchase, storage, handling, use, and disposal in accordance with applicable regulations and approved laboratory procedures.

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Protected by Design

Peptide and diluent remain separate until preparation

≥98% Purity

HPLC verified for research grade quality

Controlled Conditions

Prepared with a focus on consistency and research quality

Certificate of Analysis

Provided with Every Lot

Scientific Overview

Scientific Background

Semax is a synthetic peptide composed of seven amino acids, with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. It was developed from ACTH(4–7)—the Met-Glu-His-Phe fragment of adrenocorticotropic hormone—with a Pro-Gly-Pro extension that gives Semax greater stability without retaining the hormonal activity of ACTH.

Its structure provides an interesting example of how modifying a short natural peptide fragment can significantly change its biological properties. Rather than acting through one established receptor, Semax has been investigated across several interconnected pathways involving neurotrophic factors, neurotransmitter signalling and gene regulation.

A particularly important area of research involves BDNF and other neurotrophic signalling, which is closely connected with neuroplasticity, learning, memory and the formation and maintenance of neuronal connections. Experimental studies have also examined Semax in relation to oxidative and inflammatory stress, neuronal protection and cellular adaptation.

These characteristics make Semax useful for investigating how a relatively small peptide can influence cognitive processes, neuronal resilience and the brain’s response to stress, while also helping researchers understand the relationship between peptide structure and biological activity.

This information is provided as general scientific background for laboratory research purposes.
Research Context

Research Applications

Areas examined within controlled laboratory research.

Semax is a synthetic seven-amino-acid peptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. It was developed from the ACTH(4–7) fragment Met-Glu-His-Phe, with a Pro-Gly-Pro extension that increases the stability of the peptide without retaining the hormonal activity associated with ACTH.

Research into Semax has focused particularly on cognitive function, learning, memory and attention, as well as the biological mechanisms involved in neuronal protection and adaptation. Studies have examined its influence on neurotrophic factors such as BDNF, gene expression and signalling pathways associated with neuronal growth and plasticity.

These properties make Semax particularly interesting for investigating neuroplasticity, cognitive performance and neuronal responses to stress, including how changes in neurotrophic signalling may influence the brain’s ability to adapt and maintain neural connections.

Current areas of scientific investigation include:

  1. Neurotrophic-factor signalling (Semax)

    Research examining Semax in connection with the expression and regulation of neurotrophic factors involved in neuronal maintenance, adaptation and cellular communication.

  2. Gene-expression responses (Semax)

    Studies investigating changes in gene activity associated with Semax exposure across controlled biochemical, cellular and preclinical research models.

  3. Neurotransmitter-associated pathways (Semax)

    Experimental investigation of Semax in relation to signalling pathways involving dopamine, serotonin and other neurotransmitter-associated systems.

  4. Cellular stress and adaptation (Semax)

    Research exploring cellular responses to oxidative stress, inflammatory conditions, oxygen restriction and other controlled experimental challenges.

  5. Neuronal signalling models (Semax)

    Studies examining how Semax interacts with molecular processes associated with neuronal communication, plasticity and functional adaptation.

  6. Peptide structure and stability (Semax)

    Investigation of how the ACTH(4–7) fragment and Pro-Gly-Pro extension influence the compound’s stability, molecular interactions and experimental behaviour.

Studies of Semax have explored its effects on learning, memory, attention and cognitive performance, alongside the molecular processes that support neuronal function and adaptation. Research has reported changes in neurotrophic signalling and gene expression, including pathways associated with BDNF, an important protein involved in neuronal plasticity.

Semax has also been investigated in experimental models of cellular and neurological stress, where researchers have examined its relationship with neuronal protection, recovery and the brain’s ability to adapt to challenging conditions.

Together, these findings continue to build understanding of how an ACTH-derived peptide without ACTH hormonal activity may influence cognition, neuroplasticity and neuronal resilience.

For laboratory research purposes only. Not intended for human or veterinary use.

Important Notice Research Use Only View complete notice

All products supplied by Pencell Peptide (PCP), including its dual-chamber peptide research pens, are intended strictly for laboratory research purposes only.

These products are not intended for human or animal consumption, medical or veterinary use, therapeutic applications, diagnostic procedures or any other clinical purpose.

Customers are responsible for complying with all applicable laws, regulations and institutional requirements governing the purchase, possession, handling, storage and use of peptide research materials.

Read the complete Research Use Only notice .